Endocrine Abstracts

Hypoestrogenemia is associated with dislipidemia and is an independent risk factor for cardiovascular diseases in postmenopausal women. However, there is a cohort of young women with gonadal steroid deficit caused by the disorders of central regulation. Twenty women with hypogonadotropic hypogonadism (HH) were included in group 1. (median age - 29 years and 3 months, median duration of amenorhea - 5 years 3 months, mean BMI - 24.6±6.05 kg/cm2. Women were examined before a...

Objectives: To assess prevalence of antipsychotic-induced hyperpolactinemia (AIH) in psychiatric in-patients and to describe its clinical characteristics and association of AIH with sexual function.Methods: A cross-sectional study in 143 consecutive psychiatric in-patients (F/M=65/78), mostly with schizophrenia (93%), currently taking antipsychotics. The patients were screened for serum prolactin, sex hormones, gonadotropin levels and macroprolactin. For...

We examined 56 normoprolactinemic women of reproductive age (18–45 y.o.) with isolated hypogonadotropic hypogonadism (group 1) initially and on treatment with 2 mg of 17β-estradiol and 10 mg of dydrogesterone in sequenced manner (HRT), duration of HRT was from 18 to 42 (median 36) months; 45 healthy women (20–38 y.o.) were included in control group 2.Initially hypercholesterolemia was observed in 50% of cases in group 1 and 6.6% in group 2...